Searchable abstracts of presentations at key conferences in endocrinology

ea0062p39 | Poster Presentations | EU2019

Hypophysitis secondary to pembrolizumab use in primary lung carcinoma with brain and adrenal metastasis: An evaluation of hormone replacement and future management

Khanam Amina , Mitchell Antonine Pineau , Khan Madeha , Charles Debbie-Ann , Tremble Jennifer

Case history: A 72 year old male was diagnosed with primary lung adenocarcinoma grade T4N2M1b with adrenal and brain metastasis 1 year previously. On diagnosis his tumour was strongly positive for PDL-1 expression. This patient was started on dexamethasone 8 mg once a day that was weaned down to 4mg twice daily and then slowly weaned off steroids whilst receiving whole brain radiation. He was started on pembrolizumab therapy and had received ten cycles of treatment when he beg...